Structural biology is a key step in drug discovery. It is important before screening for docking work and also during hit optimisation to visualise compound/target interactions. Structure determination is of key importance for projects targeting protein-protein interactions.

Key points

Gene to constructs

• Definition of constructs
• Multiconstruct approach
• Systematic use of activity assays (incl. delivery of constructs for screening by customer)

Crystallisation to structure resolution

• Screening in nanodrop format, optimisation in nano or micro drop format
• Co-crystallization or soaking of ligands
• Data collection In house and/or synchrotron

Applications

• New targets
• Hits , leads or products bound to targets
• Protein protein complexes